ELK Biotechnology Cathepsin B rabbit pAb
Cathepsin B rabbit polyclonal antibody로, 인간·마우스·랫트 시료에 반응합니다. WB, IHC, IF, ELISA에 사용 가능하며, 인간 Cathepsin B 유래 합성 펩타이드로 면역화되었습니다. 단백질 분해 및 APP 처리 연구에 적합합니다.
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- ES1869-xxxxx (2개 옵션)
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Cathepsin B rabbit pAb
제품 개요
Cathepsin B rabbit polyclonal antibody는 인간 Cathepsin B에서 유래한 합성 펩타이드를 면역원으로 제작된 항체입니다. 단백질 분해 효소 연구, APP 처리 및 알츠하이머병 관련 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cathepsin B rabbit pAb |
| Alternative Names | CTSB; CPSB; Cathepsin B; APP secretase; APPS; Cathepsin B1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/5000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human Cathepsin B (AA range: 168–217) |
| Host Species | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38, 40, 25 kDa |
| Gene ID (Human) | 1508 |
| Human Swiss-Prot No. | P07858 |
| Cellular Localization | Lysosome, Melanosome, Secreted extracellular space, Apical cell membrane, Peripheral membrane protein (extracellular side). Detected by mass spectrometry in melanosome fractions (stage I–IV, PubMed:17081065). Localizes to lumen of thyroid follicles and apical membrane of thyroid epithelial cells (by similarity). |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the C1 family of peptidases. Alternative splicing results in multiple transcript variants, some of which encode preproproteins processed into multiple protein products, including Cathepsin B light and heavy chains that form a double-chain enzyme. This lysosomal cysteine protease exhibits both endopeptidase and exopeptidase activity, contributing to protein turnover. It also acts as amyloid precursor protein secretase, involved in APP proteolytic processing. Incomplete APP processing is implicated in Alzheimer’s disease. Overexpression has been linked to esophageal adenocarcinoma and other tumors.
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