ELK Biotechnology Caspase-3 rabbit pAb
Caspase-3 rabbit polyclonal antibody로, apoptosis 연구에 적합합니다. WB, IHC, IF, ELISA 등 다양한 응용 가능하며, 인간, 생쥐, 랫드, 어류에 반응합니다. 합성 펩타이드 면역원으로 제작되었으며, -20°C에서 1년 보관 가능합니다.
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Caspase-3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Caspase-3 rabbit pAb |
| Alternative Names | CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 IF: 1/100–1/300 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Caspase 3 (AA range: 116–165) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 35 kD |
| GeneID (Human) | 836 |
| Human Swiss-Prot No | P42574 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human; Mouse; Rat; Fish |
Background
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce large and small subunits, which dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7, and 9, and is itself processed by caspases 8, 9, and 10. It is the predominant caspase involved in cleavage of amyloid-beta 4A precursor protein, associated with neuronal death in Alzheimer’s disease. Alternative splicing results in two transcript variants encoding the same protein.
[provided by RefSeq, Jul 2008]
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