ELK Biotechnology AChRα10 rabbit pAb
인간 CHRNA10 유래 펩타이드로 제작된 rabbit polyclonal antibody. WB와 ELISA에 적합하며, 세포막 및 시냅스 단백질 검출에 활용 가능. 청각 자극 조절 관련 연구에 유용. -20°C에서 1년 보관.
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ELK Biotechnology AChRα10 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | AChRα10 rabbit pAb |
| Alternative Names | CHRNA10; NACHRA10; Neuronal acetylcholine receptor subunit alpha-10; Nicotinic acetylcholine receptor subunit alpha-10; NACHR alpha-10 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CHRNA10 (AA range: 394-443) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| Gene ID (Human) | 57053 |
| Human Swiss-Prot No. | Q9GZZ6 |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein; Cell membrane |
| Species Reactivity | Human; Mouse; Rat |
Background
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive conformational change affecting all subunits and leading to the opening of an ion-conducting channel across the plasma membrane. The channel is permeable to divalent cations including calcium, whose influx may activate a potassium current that hyperpolarizes the cell membrane. In the ear, this may reduce basilar membrane motion, alter auditory nerve fiber activity, and protect against acoustic trauma.
The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Forms hetero-oligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers. Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells, and peripheral blood lymphocytes.
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