ELK Biotechnology Cleaved-Cathepsin D LC (G65) rabbit pAb
Cleaved-Cathepsin D LC (G65) rabbit pAb는 인간 유래 CATD 펩타이드로부터 제작된 폴리클로날 항체입니다. WB와 ELISA에 사용 가능하며, 단백질 전환 및 성장 인자 활성화 연구에 적합합니다. -20°C에서 1년 보관 가능합니다.
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Cleaved-Cathepsin D LC (G65) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Cleaved-Cathepsin D LC (G65) rabbit pAb |
| Alternative Names | CTSD; CPSD; Cathepsin D |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CATD. AA range: 46–95 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 17 kD |
| Gene ID (Human) | 1509 |
| Human Swiss-Prot No. | P07339 |
| Species Reactivity | Human; Monkey |
| Cellular Localization | Lysosome; Melanosome; Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). |
Background
This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products, including cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene are associated with neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer’s disease.
[Provided by RefSeq, Nov 2015]
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