ELK Biotechnology Ob-R (phospho Tyr1141) rabbit pAb
Ob-R (phospho Tyr1141) rabbit polyclonal antibody for WB and ELISA applications. Recognizes leptin receptor involved in fat metabolism and lymphopoiesis. High specificity, stable at -20°C for 1 year, suitable for human and mouse samples.
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제품명
Ob-R (phospho Tyr1141) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
이 항체는 인간 Ob-R 단백질의 Tyr1141 인산화 부위를 중심으로 합성된 인산화 펩타이드로부터 제작된 rabbit polyclonal antibody입니다. 지방 대사 및 림프구 생성에 관여하는 leptin receptor를 인식합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | LEPR; DB; OBR; Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD antigen CD295 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Ob-R (phospho Tyr1141) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 132 kD |
| GeneID (Human) | 3953 |
| Human Swiss-Prot No | P48357 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Basolateral cell membrane; Isoform E: Secreted |
Background
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that stimulate gene transcription via activation of cytosolic STAT proteins. It acts as a receptor for leptin, an adipocyte-specific hormone regulating body weight, and is involved in fat metabolism and hematopoietic pathways required for normal lymphopoiesis. Mutations in this gene are associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described. This gene and LEPROT gene (GeneID:54741) share the same promoter and the first two exons but encode distinct proteins (PMID:9207021). [provided by RefSeq, Nov 2010]
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