ELK Biotechnology p38 (phospho Thr180/Y182) rabbit pAb
p38 MAPK 인산화 Thr180/Y182 인식 토끼 폴리클로날 항체로, 세포 내 스트레스 반응 및 신호전달 연구에 적합. WB, IF, IHC, Flow Cyt, ELISA 등 다양한 응용 가능. 인산화 부위 특이적 검출에 유용하며 인체, 마우스, 랫트 등에서 반응.
- 판매단위
- pk
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제품명
p38 (phospho Thr180/Y182) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein |
| Applications | IF; WB; Flow Cyt; IHC; ELISA |
| Recommended Dilutions | IF/ICC 1:100–500; WB 1:500–2000; Flow Cyt 1:50–200; IHC-p 1:100–500; ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human p38 MAPK around the phosphorylation site of Thr179 and Tyr181 (AA range: 151–200) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kDa |
| Gene ID (Human) | 1432 |
| Human Swiss-Prot No | Q16539 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Mouse, Rat, Guinea pig |
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in various cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is activated by environmental stresses and proinflammatory cytokines. Activation requires phosphorylation by MAP kinase kinases (MKKs) or autophosphorylation triggered by interaction with MAP3K7IP1/TAB1. Substrates include transcription regulators ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, suggesting roles in stress-related transcription, cell cycle regulation, and genotoxic stress response. Four alternatively spliced transcript variants of this gene have been identified.
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