ELK Biotechnology Flt-1 (phospho Tyr1213) rabbit pAb
Flt-1 (phospho Tyr1213) rabbit polyclonal antibody로 VEGFR1 인산화 형태를 검출. WB 및 ELISA에 적합하며 인간, 생쥐, 랫트 시료에 반응. 고순도 IgG, 1 mg/ml 농도로 제공되며 -20°C에서 1년 보관 가능.
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제품명
Flt-1 (phospho Tyr1213) rabbit pAb
공급업체
ELK Biotechnology
제품 설명
이 항체는 인간 Flt-1 (phospho Tyr1213) 부위 주변에서 합성된 인산화 펩타이드를 면역원으로 제작된 rabbit polyclonal antibody입니다. VEGFR1의 인산화 상태를 검출하며 혈관 형성 및 혈관발생 연구에 활용됩니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | FLT1; FLT; FRT; VEGFR1; Vascular endothelial growth factor receptor 1; VEGFR-1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular permeability factor receptor |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Flt-1 (phospho Tyr1213) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 150 kD |
| GeneID (Human) | 2321 |
| Human Swiss-Prot No | P17948 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
- Isoform 1: Cell membrane; Single-pass type I membrane protein. Endosome. Autophosphorylation promotes ubiquitination and endocytosis.
- Isoform 2–4: Secreted
- Isoform 5–7: Cytoplasm
Background
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B, and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells, and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
[provided by RefSeq, May 2009]
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