ELK Biotechnology ACCα (phospho Ser80) rabbit pAb
인산화 Ser80 부위를 인식하는 ACCα 폴리클로날 항체로, WB·IHC·IF·ELISA에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 세포질 ACC1 단백질 검출에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
ACCα (phospho Ser80) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ACACA; ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Acetyl-CoA Carboxylase around the phosphorylation site of Ser80 (AA range: 46–95) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 280 kD |
| GeneID (Human) | 31 |
| Human Swiss-Prot No | Q13085 |
| Cellular Localization | Cytoplasm, cytosol |
| Species Reactivity | Human; Mouse; Rat |
Background
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. It is a biotin-containing enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is regulated both long-term (transcriptional and translational levels) and short-term (phosphorylation/dephosphorylation of serine residues and allosteric transformation by citrate or palmitoyl-CoA). Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
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