ELK Biotechnology LIMK-1/2 (phospho Thr508/505) rabbit pAb

제품명

LIMK-1/2 (phospho Thr508/505) rabbit pAb

대체 명칭

LIMK1; LIMK; LIM domain kinase 1; LIMK-1; LIMK2; LIM domain kinase 2; LIMK-2

적용 분야

WB, IHC, IF, ELISA

권장 희석 배수

• WB: 1:500–2000
• IHC-p: 1:100–500
• IF/ICC: 1:100–500
• ELISA: 1:5000–20000

면역원

Synthesized phospho-peptide around the phosphorylation site of human LIMK-1/2 (phospho Thr508/505)

보관 조건

-20°C / 1 year

항체 정보

세포 내 위치

Cytoplasm, Nucleus, Cytoskeleton, Cell projection (lamellipodium).
Predominantly found in the cytoplasm and localizes in the lamellipodium in a CDC42BPA, CDC42BPB, and FAM89B/LRAP25-dependent manner.

배경 정보

There are approximately 40 known eukaryotic LIM proteins, named for their LIM domains. LIM domains are conserved cysteine-rich structures containing two zinc fingers, typically mediating protein-protein interactions. LIM kinase-1 and LIM kinase-2 form a subfamily with two N-terminal LIM motifs and a C-terminal kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of cofilin. This protein is ubiquitously expressed during development, plays a role in cytoskeletal organization, stimulates axon growth, and may contribute to brain development. LIMK1 hemizygosity is implicated in impaired visuospatial constructive cognition.