ELK Biotechnology Akt (phospho Thr308) rabbit pAb

Akt (phospho Thr308) rabbit pAb

제품 정보

Cellular Localization

Cytoplasm, nucleus, and cell membrane. Translocates to the nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane, where further phosphorylations on Thr-308 and Ser-473 lead to activation. The activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529).

Background

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and AKT2 are activated by platelet-derived growth factor through the phosphatidylinositol 3-kinase pathway. In the developing nervous system, AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors suppress apoptosis by activating AKT1, which phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene are associated with Proteus syndrome. Multiple alternatively spliced transcript variants exist (RefSeq, Jul 2011).