ELK Biotechnology Smad2 (phospho Ser467) rabbit pAb
Smad2 단백질의 Ser467 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 세포 내 TGF-β 신호전달 연구에 적합. -20°C에서 장기 보관 가능.
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제품명
Smad2 (phospho Ser467) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Smad2 around the phosphorylation site of Ser467 (AA range: 418–467) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 58 kDa |
| Gene ID (Human) | 4087 |
| Human Swiss-Prot No. | Q15796 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm and nucleus.
Cytoplasmic and nuclear in the absence of TGF-beta. Upon TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696, PubMed:21145499).
Dephosphorylation by phosphatase PPM1A releases it from the SMAD2/SMAD4 complex, allowing export from the nucleus via interaction with RANBP1 (PubMed:16751101, PubMed:19289081).
Localized mainly to the nucleus in early embryo development, later expressed in the cytoplasm at blastocyst and epiblast stages (By similarity).
Background
The protein encoded by this gene belongs to the SMAD family, homologous to the Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma genes.
SMAD proteins act as signal transducers and transcriptional modulators mediating multiple signaling pathways.
This protein mediates the TGF-beta signal and regulates cellular processes such as proliferation, apoptosis, and differentiation.
It is recruited to TGF-beta receptors via interaction with SARA (SMAD anchor for receptor activation).
Upon TGF-beta stimulation, it is phosphorylated by TGF-beta receptors, leading to dissociation from SARA and association with SMAD4, which is critical for nuclear translocation and subsequent signal transduction.
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