ELK Biotechnology MSK1 (phospho Ser376) rabbit pAb

제품명

MSK1 (phospho Ser376) rabbit pAb

공급업체

ELK Biotechnology

제품 설명

MSK1 (phospho Ser376) rabbit polyclonal antibody는 인간 MSK1 단백질의 Ser376 인산화 부위를 인식하도록 제작된 항체입니다. Mitogen 및 stress 신호에 의해 활성화되는 전사 인자 CREB, ATF1, 그리고 히스톤 H3의 인산화를 조절하는 핵심 효소인 MSK1을 검출할 수 있습니다.

제품 스펙

Background

• Catalytic activity: ATP + a protein = ADP + a phosphoprotein
• Cofactor: Magnesium
• Enzyme regulation: Activated by multiple phosphorylations on threonine and serine residues; ERK1/2 and MAPK14/p38-alpha may be involved
• Function: Serine/threonine kinase required for mitogen- or stress-induced phosphorylation of transcription factors CREB and ATF1; controls RELA transcriptional activity in response to TNF; phosphorylates histone H2A (Ser-1) and H3 (Ser-10, Ser-28) leading to transcriptional activation of immediate early genes (e.g., c-fos, c-jun); phosphorylates HMG-14
• Miscellaneous: Enzyme activity requires both kinase domains
• PTM: Ser-376 and Thr-581 phosphorylation required for kinase activity; Ser-376 and Ser-212 autophosphorylated by the C-terminal kinase domain
• Similarity: Belongs to protein kinase superfamily (AGC Ser/Thr family, S6 kinase subfamily); contains 1 AGC-kinase C-terminal domain and 2 protein kinase domains
• Subcellular location: Predominantly nuclear, partially cytoplasmic
• Subunit: Forms a complex with ERK1/2 and MAPK14/p38-alpha; phosphorylates NF-κB p65 subunit RELA
• Tissue specificity: Widely expressed with high levels in heart, brain, and placenta; lower levels in lung, kidney, and liver

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