ELK Biotechnology Akt (phospho Tyr326) rabbit pAb

제품명

Akt (phospho Tyr326) rabbit pAb

제품 개요

본 항체는 인간 Akt 단백질의 Tyr326 인산화 부위를 인식하도록 제작된 rabbit polyclonal antibody입니다. 세포 내 Akt 신호전달 및 인산화 연구에 활용할 수 있습니다.

제품 스펙

세포 내 위치

Cytoplasm, Nucleus, Cell membrane.
Nucleus after activation by integrin-linked protein kinase 1 (ILK1).
Nuclear translocation is enhanced by interaction with TCL1A.
Phosphorylation on Tyr-176 by TNK2 results in localization to the cell membrane, enabling further phosphorylations on Thr-308 and Ser-473 leading to activation.
Activated form translocates to the nucleus.
Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529).

Background

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts.
AKT1 and AKT2 are activated by platelet-derived growth factor via phosphatidylinositol 3-kinase.
In the developing nervous system, AKT acts as a critical mediator of growth factor-induced neuronal survival.
Survival factors suppress apoptosis by activating AKT1, which phosphorylates and inactivates apoptotic components.
Mutations in this gene are associated with Proteus syndrome.
Multiple alternatively spliced transcript variants have been identified (RefSeq, Jul 2011).