Thermo Fisher Scientific Tubulin alpha-1B Recombinant Rabbit Monoclonal Antibody (8E8W9)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Positive test controls include: HeLa, PC-12, A-549, NIH/3T3, U-251MG, Mouse brain, Rat brain.

Target Information

Microtubules are intracellular dynamic polymers composed of conserved alpha/beta-tubulin heterodimers and microtubule-associated proteins (MAPs). They exhibit intrinsic polarity with dynamic plus ends and less dynamic minus ends, essential for processes such as mitosis, meiosis, cell shape maintenance, and intracellular transport. Microtubules also enable cell movement via flagella and cilia. In mammalian cells, minus ends are anchored in microtubule organizing centers (MTOCs). GTP is crucial for tubulin dimer association and microtubule formation. Microtubule polymerization is reversible, and dynamic instability describes alternating growth and shortening at minus ends. Alpha-tubulin (~50 kDa) exists as soluble dimers or polymerized microtubules, encoded by multiple tubulin genes forming distinct classes (six in humans).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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