Thermo Fisher Scientific ErbB4 Recombinant Rabbit Monoclonal Antibody (049)
Mouse ErbB4/HER4 단백질을 인식하는 recombinant rabbit monoclonal antibody. 높은 특이성과 재현성을 제공하며, preservative-free 포뮬레이션. ELISA에 적합하며, 일관된 로트 간 성능 유지. 단기 4°C, 장기 -20°C 보관 권장.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific ErbB4 Recombinant Rabbit Monoclonal Antibody (049)
Applications and Tested Dilution
- ELISA (ELISA): 1:5,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 049 |
| Immunogen | Recombinant Mouse ErbB4/HER4 Protein (Met1–Leu652) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2786776 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to large rabbit immune repertoire
This antibody has specificity for Mouse ErbB4/HER4.
Target Information
The ERBB4 (HER4) oncogene encodes a member of the type I receptor protein tyrosine kinase subfamily, which includes EGFR, ERBB2, and ERBB3. ERBB4 binds and is activated by neuregulins and other factors, inducing cellular responses such as mitogenesis and differentiation.
Functional roles:
- Mediates HGL-stimulated tyrosine phosphorylation
- Regulates metabolism, transcription, cell cycle, cytoskeletal rearrangement, apoptosis, and differentiation
- Highly expressed in several breast carcinoma cell lines and normal tissues (skeletal muscle, heart, pituitary, brain, cerebellum)
- Elevated ERBB4 levels observed in certain tumor cell lines, suggesting a role in malignancies
Note: For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.