Thermo Fisher Scientific Lamin B2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Lamin B2. Validated for Western blot applications. Purified by antigen affinity chromatography, supplied as a liquid at 0.5 mg/mL in PBS with 40% glycerol. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human LMNB2. Recombinant protein control fragment (Product # RP-104279) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791039 |
Product Specific Information
Immunogen sequence:
DEVNKSAKKR EGELTVAQGR VKDLESLFHR SEVELAAALS DKRGLESDVA ELRAQLAKAE DGHAVAKKQL EKETLM
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic side of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins.
- A-type lamins: Lamin A, Lamin C, and Lamin Adel 10 (from alternative splicing of the same gene)
- B-type lamins: Lamin B1 and Lamin B2 (encoded by distinct genes)
Mutations in A-type lamins are associated with several genetic disorders such as Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease, and Dunnigan-type familial partial lipodystrophy.
A-type lamins are expressed during cell differentiation and interact with chromatin, suggesting a role in regulating differential gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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