Thermo Fisher Scientific Phospho-IKKi (Thr501) Polyclonal Antibody
Phospho-IKKi (Thr501) 인산화 부위에 특이적인 Rabbit Polyclonal 항체. WB, IHC, ICC, ELISA 등 다양한 응용 가능. Human 시료 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 연구용 전용 제품.
- 카탈로그번호
- BS-7601R
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-IKKi (Thr501) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human IKKi/IKKe around the phosphorylation site of Thr501 [LR(p-T)LA] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA and 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IKBKE (IKKi/IKKε) is an activator of nuclear factor-kappa-B (NF-κB). Overexpression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death.
NF-κB is a ubiquitous transcription factor and an essential mediator of gene expression during immune and inflammatory responses.
It is associated with IκB proteins in the cytoplasm, which inhibit NF-κB activity. IκB is phosphorylated by the IKK complex containing IKK-α, IKK-β, and IKK-γ.
A novel molecule in this complex, IKK-ι/IKK-i (IKK epsilon), is required for NF-κB activation by PMA and T cell receptors but not by TNF-α and IL-1.
IKK-ι/IKK-i is expressed in various tissues and is inducible by TNF-α, IL-1, and LPS.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.