Thermo Fisher Scientific CA19-9/Sialyl Lewisa (GI Tumor Marker) Monoclonal Antibody (SPM588)
CA19-9/Sialyl Lewisa 단일클론 항체(SPM588)는 GI 종양 마커 검출용으로 개발된 Mouse IgM 항체입니다. IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합하며, 인간 시료에 반응합니다. 단백질 A/G 정제, PBS buffer에 보존되어 연구용으로 사용됩니다.
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Thermo Fisher Scientific CA19-9/Sialyl Lewisa (GI Tumor Marker) Monoclonal Antibody (SPM588)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM588 |
| Immunogen | Precipitin lines obtained after immuno-diffusion using MAb 116-NS-19-9 and mucins isolated from an ovarian cyst of a Lewis A+B- patient (0Le). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Mucin glycoprotein is a Sialyl Lewis A structure synthesized from type 1 blood group precursor chains and present in individuals expressing Lewis A and/or Lewis B blood group antigens.
In normal tissues, sialyl Lewis A antigen is found in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum and in most gastrointestinal (GI) carcinoma cells, including adenocarcinomas of the stomach, intestine, and pancreas.
Preoperative elevated CA19-9 levels in stage I pancreatic carcinoma patients typically return to normal following surgery. Serial CA19-9 measurement can predict recurrence prior to radiographic or clinical detection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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