Thermo Fisher Scientific CA19-9/Sialyl Lewisa (GI Tumor Marker) Monoclonal Antibody (SPM588)
CA19-9/Sialyl Lewis A 단일클론 항체(SPM588)는 GI 종양 마커 검출용으로 개발된 항체로, 인간 반응성 및 IHC, ICC, Flow Cytometry 등 다양한 응용에 적합합니다. 단백질 A/G 정제, 액상 형태, 4°C 보관.
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Thermo Fisher Scientific CA19-9/Sialyl Lewis A (GI Tumor Marker) Monoclonal Antibody (SPM588)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM588 |
| Immunogen | Precipitin lines obtained after immuno-diffusion using MAb 116-NS-19-9 and mucins isolated from an ovarian cyst of a Lewis A+B- patient (0Le). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Mucin glycoprotein is a Sialyl Lewis A structure synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewis A and/or Lewis B blood group antigens.
In normal tissues, sialyl Lewis A antigen is found in ductal epithelium of the breast, kidney, salivary gland, and sweat glands.
Its expression is greatly enhanced in serum and in most tumor cells of gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas.
Preoperative elevated CA19-9 levels in stage I pancreatic carcinoma patients decrease to normal values following surgery. When used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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