Thermo Fisher Scientific CD120a (TNF Receptor I) Monoclonal Antibody (H398), eBioscience

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Neutralization (Neu)

• Not specified

Functional Assay

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

The monoclonal antibody H398 recognizes the extracellular domain of Tumor Necrosis Factor Receptor type I (TNF-RI), detecting both membrane-bound and soluble receptor forms.
It is suitable for immunoassay, flow cytometry, immunoprecipitation, Western blotting, and immunohistology on frozen sections.
This antibody can act as an antagonistic antibody in functional studies and competes with TNF-alpha.

• Applications Tested: Flow Cytometry, Functional Studies (Blocking), Immunohistochemistry (Frozen)
• Purity: >95%

Target Information

TNFR1 (Tumor Necrosis Factor Receptor 1) is part of the TNF superfamily and serves as a major receptor for TNF-alpha.
It plays a key role in:

• Cytokine-mediated signaling
• Positive regulation of the NF-κB pathway
• Regulation of angiogenesis and gene expression

The extracellular domain of TNFR1 can be released as soluble TNFR1 (sTNFR1).
In humans, the TNFR1 gene is located on chromosome 12.
Proteins such as BAG4/SODD, TRADD, and TRAF2 interact with TNFR1, modulating its signal transduction.
Mutations in the extracellular domain are linked to autosomal dominant periodic fever syndrome, associated with impaired receptor clearance.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.