Thermo Fisher Scientific MKP3 Polyclonal Antibody
MKP3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. KLH 결합 합성 펩타이드 항원 사용. 고순도 정제 및 안정적 보관 용이.
- 카탈로그번호
- PA515552
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 58–89 amino acids from the central region of human DUSP6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion dialysis, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2261935 |
Product Specific Information
This antibody is predicted to react with bovine based on sequence homology.
Target Information
DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.
Different members of this family show distinct substrate specificities, tissue distribution, subcellular localization, and expression inducibility by extracellular stimuli. DUSP6 inactivates ERK2, is expressed in various tissues with highest levels in heart and pancreas, and is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for the DUSP6 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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