Thermo Fisher Scientific PRL1 Polyclonal Antibody
PRL1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western Blot에 적합합니다. Human 및 Mouse 시료에 반응하며, 비결합(Unconjugated) 상태로 제공됩니다. 암모늄 황산염 침전 및 크기 배제 정제로 정제되었으며, PBS(pH 7.4) 용액에 0.09% sodium azide를 포함합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encoding full length of human PRL1 (UniProt ID: Q93096-1, Antigen Range: 1–173) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2237952 |
Target Information
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in various cellular processes. This tyrosine phosphatase is a nuclear protein but may primarily associate with the plasma membrane. Its membrane association depends on its C-terminal prenylation. Overexpression in mammalian cells confers a transformed phenotype, implicating its role in tumorigenesis. Studies in rats suggest this gene may act as an immediate-early gene in mitogen-stimulated cells. PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase. PRL-1 function is regulated in a cell cycle-dependent manner and may regulate progression through mitosis by modulating spindle dynamics.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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