Thermo Fisher Scientific Cytokeratin 18 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended positive controls: A431, H1299, HeLa, HepG2, Molt-4, Raji
• Predicted reactivity: Mouse (86%), Rat (85%), Dog (90%), Bovine (91%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 8.
It is expressed in tissues from gastrointestinal, respiratory, and urogenital tracts, as well as endocrine, exocrine, and mesothelial cells.
Cytokeratin 18 is primarily found in non-squamous epithelia and is present in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas.
Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis.
Two transcript variants encoding the same protein have been identified.
Cytokeratin subtype expression patterns aid in distinguishing epithelial malignancies and serve as valuable tools in immunohistochemistry, cytopathology, and flow cytometric assays.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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