Thermo Fisher Scientific Tau Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: mouse brain, rat brain
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both structures.

Tau localization defines axonal polarity in neurons. Short isoforms contribute to cytoskeletal plasticity, while longer isoforms stabilize it. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), forming neurofibrillary lesions characteristic of Alzheimer’s disease (AD). Hyper-phosphorylation impairs microtubule binding, leading to neuronal degeneration in AD.

Tau phosphorylation is mediated by several kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also implicated in other neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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