Thermo Fisher Scientific Aggrecan Recombinant Rabbit Monoclonal Antibody (JA40-23)
Recombinant rabbit monoclonal antibody targeting human Aggrecan, optimized for IHC applications. Offers high specificity, sensitivity, and lot-to-lot consistency. Produced via HEK293 expression system; unconjugated, liquid form, 1 mg/mL concentration. ...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA40-23 |
| Immunogen | Recombinant protein within Human Aggrecan aa 742–881 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809972 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select optimal candidates for production.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is encoded by the ACAN gene.
This protein is a key component of the extracellular matrix in cartilaginous tissue, providing resistance to compression. The human form (≈250 kDa, 2316 amino acids) exists in multiple isoforms via alternative splicing.
Aggrecan has a bottlebrush structure with chondroitin sulfate and keratan sulfate chains attached to its core. It contains three interglobular domains (G1, G2, G3) involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis.
Aggrecan fragments are released into synovial fluid during all stages of osteoarthritis due to cleavage by aggrecanase and MMP. Antibodies BC-3 and BC-4 detect neo epitopes of Aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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