Thermo Fisher Scientific Zika Virus NS1 (strain Zika SPH2015) Monoclonal Antibody (03)

Applications

• ELISA (ELISA): 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-NS1.

Target Information

As a member of the Flaviviridae family, ZIKV has a single positive-sense RNA genome, which is initially translated as a single polyprotein. This polyprotein is cleaved post-translationally into three structural proteins (C, PrM or M, and E) and seven nonstructural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5).
The glycosylated NS1 forms a homodimer inside the cells and is necessary for viral replication and late infection stages. NS1 is also secreted into the extracellular space as a hexameric lipoprotein particle, which assists the virus in immune evasion and pathogenesis by interacting with components of both innate and adaptive immune systems as well as other host factors.

References:
1) Song, H.; Qi, J.; Haywood, J.; Shi, Y.; Gao, G.F. (2016). Nat. Struct. Mol. Biol. 23, 456–458.
2) Suthar, M.S., Diamond, M.S. & Gale, M. Jr. (2013). Nat. Rev. Microbiol. 11, 115–128.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.