Thermo Fisher Scientific Zika Virus Envelope (Domain III) (strain Zika SPH2015) Recombinant Rabbit Monoclonal Antibody (033)

Applications

ELISA

• Tested Dilution: 1:1,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal-origin-free formulations
• Broader immunoreactivity to diverse targets due to the larger rabbit immune repertoire

This antibody has specificity for Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E/Envelope protein (Domain III).

Target Information

Zika virus (ZIKV), a member of the Flaviviridae family, has a single positive-sense RNA genome initially translated as a single polyprotein, which is post-translationally cleaved into structural proteins (C, PrM/M, E) and nonstructural proteins (NS1–NS5). The glycosylated NS1 forms a homodimer inside cells, essential for viral replication, and later secreted as a hexameric lipoprotein particle aiding immune evasion and pathogenesis by interacting with host immune components.

References:

1. Song, H.; Qi, J.; Haywood, J.; Shi, Y.; Gao, G.F. (2016). Nat. Struct. Mol. Biol. 23, 456–458.
2. Suthar, M.S., Diamond, M.S., and Gale, M. Jr. (2013). Nat. Rev. Microbiol. 11, 115–128.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.