Thermo Fisher Scientific UBE2B Polyclonal Antibody
Thermo Fisher Scientific의 UBE2B Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 토끼 유래 다클론 항체입니다. Western blot 및 ELISA에 적합하며, DNA 손상 복구 관련 단백질 UBE2B를 검출합니다. 고순도 친화 크로마토그래피 정제, 안정한 PBS/glycerol 포뮬레이션으로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–152 of human UBE2B (NP_003328.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.61 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914558 |
Product Specific Information
Positive test controls include: MCF7, SW480, Jurkat, NIH/3T3, Mouse heart, Mouse brain, Mouse skeletal muscle, Rat heart, Rat brain.
The target is usually found in the following locations: Cell membrane, Nucleus.
Immunogen sequence:
MSTPARRRLM RDFKRLQEDP PVGVSGAPSE NNIMQWNAVI FGPEGTPFED GTFKLVIEFS EEYPNKPPTV RFLSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS PANSQAAQLY QENKREYEKR VSAIVEQSWN DS
Target Information
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
Ubiquitination involves at least three classes of enzymes:
- Ubiquitin-activating enzymes (E1s)
- Ubiquitin-conjugating enzymes (E2s)
- Ubiquitin-protein ligases (E3s)
UBE2B is a member of the E2 ubiquitin-conjugating enzyme family and is required for post-replicative DNA damage repair.
Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, indicating that this enzyme is highly conserved in eukaryotic evolution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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