Thermo Fisher Scientific GFI1b Polyclonal Antibody
Human GFI1b 단백질(aa21–aa170)에 대응하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. WB 및 ICC/IF에 사용 가능하며, Protein G로 정제된 액상 형태. 인간 반응성 외에 원숭이, 말, 돼지, 염소에서도 예측 반응. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Protein corresponding to human GFI1b (aa21–aa170) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 30% glycerol, 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724363 |
Product Specific Information
This antibody is predicted to react with Monkey, Horse, Pig, and Goat.
Target Information
GFI1b (zinc finger protein GFI-1b) is an essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. It is part of the RCOR-GFI-KDM1A-HDAC complex that suppresses genes involved in multilineage blood cell development through histone deacetylase (HDAC) recruitment.
GFI1b acts as a transcriptional repressor or activator depending on promoter and cell type context, repressing SOCS1 and SOCS3 promoter activity to regulate cytokine signaling pathways. It cooperates with GATA1 to repress target gene transcription such as BCL2L1, and silencing of GFI1B in leukemic cell lines markedly increases apoptosis rate.
Mutations in GFI1B are associated with Bleeding disorder, platelet-type 17 (BDPLT17).
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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