Thermo Fisher Scientific MEK1 C-Term Polyclonal Antibody, Biotin
Biotin으로 표지된 Rabbit Polyclonal Anti-MEK1 항체로 인간, 마우스, 랫트 반응성. Western blot 및 ELISA에 적합하며 MEK1 C-말단 특이적. 안정적이고 고순도 친화 크로마토그래피 정제 제품으로 연구용에 적합.
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Thermo Fisher Scientific MEK1 C-Term Polyclonal Antibody, Biotin
Applications and Tested Dilution
- Western Blot (WB): 1 µg/mL
- ELISA: 1:40,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acid residues near the C-terminus of MEK1 conjugated to KLH |
| Conjugate | Biotin |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 10 mg/mL BSA, 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at 4°C prior to restoration. For extended storage, aliquot contents and freeze at -20°C or below. Avoid freeze/thaw cycles. Centrifuge product if not clear after standing at room temperature. Stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This biotin-conjugated, affinity-purified antibody is directed against human MEK1 protein. Cross-reactivity is expected with human, mouse, and rat based on sequence identity of the peptide immunogen. This antibody does not react with the MEK2 isoform.
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase functioning in mitogen-activated protein kinase (MAPK) cascades that control cell growth and differentiation. It is activated by various growth factors, cytokines, membrane depolarization, and calcium influx. MEK1 activation occurs via phosphorylation at serine 218 and 222 residues by Raf1. It is involved in stress response signaling, apoptosis, and proliferation induced by cytokines. Mutations in MAP2K1 may lead to cardiofaciocutaneous syndrome.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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