Thermo Fisher Scientific Human APOBEC3G Synthetic Peptide
인간 APOBEC3G의 N-말단 15개 아미노산 서열 기반 합성 펩타이드입니다. 항체 PA5-20052의 블로킹 펩타이드로 사용 가능하며, 순도 높은 액상형 제품입니다. PBS 버퍼(pH 7.2, 0.1% BSA)로 보관하며, -20°C에서 안정적으로 저장됩니다.
- 카탈로그번호
- PEP0171
- 판매단위
- pk
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the amino terminus of human APOBEC3G.
PEP-0171 can be used as a blocking peptide with polyclonal antibody PA5-20052.
Target Information
The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates. Similar to TRIM5-a which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated into HIV-1 virions and induce hypermutation in the newly synthesized viral DNA, thereby destabilizing the viral genome. This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G; a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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