Thermo Fisher Scientific PDCD1 Monoclonal Antibody (5F5)
Human PDCD1 단백질을 인식하는 Mouse monoclonal antibody (clone 5F5). Western blot 및 ELISA에 사용 가능하며, PBS buffer에 보존된 액상형 제품. 면역억제 수용체 PD-1 연구에 적합. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5F5 |
| Immunogen | PDCD1 (AAH74740.1, 22 a.a. ~170 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GWFLDSPDRP WNPPTFSPAL LVVTEGDNAT FTCSFSNTSE SFVLNWYRMS PSNQTDKLAA FPEDRSQPGQ DCRFRVTQLP NGRDFHMSVV RARRNDSGTY LCGAISLAPK AQIKESLRAE LRVTERRAEV PTAHPSPSPR PAGQFQTLV
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express inhibitory receptors such as PD-1 (PDCD-1), which bind ligands PDL-1 and PDL-2 to downregulate immune activation. PD-1 signaling inhibits immune responses in the absence of danger signals such as LPS. PD1-deficient mice show hyperactivated immune systems and autoimmune phenotypes. Although PD-1 has a predicted molecular weight, it often migrates at a higher apparent weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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