Thermo Fisher Scientific PCMT1 Monoclonal Antibody (1D6)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.1 ng/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

1D6

Immunogen

PCMT1 (NP_005380, 117 a.a. approximately 225 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PCMT1,uniProtId:P22061-1,ncbiNodeId:9606,antigenRange:117-225,antigenLength:227,antigenImageFileName:H00005110-M02_PCMT1_P22061-1_House_mouse.svg,antigenImageFileNamePDP:H00005110-M02_PCMT1_P22061-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: DDSVNNVRKD DPTLLSSGRV QLVVGDGRMG YAEEAPYDAI HVGAAAPVVP QALIDQLKPG GRLILPVGPA GGNQMLEQYD KLQDGSIKMK PLMGVIYVPL TDKEKQWSR

Target Information

Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.