Thermo Fisher Scientific ATGL Polyclonal Antibody
Thermo Fisher Scientific의 ATGL Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 ATGL 단백질 검출에 적합합니다. Western blot, ICC/IF, ELISA에 사용 가능하며, 고순도 친화 크로마토그래피로 정제된 비결합형 항체입니다. 연구용으로만 사용됩니다.
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- PA5110189
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 45–257 of human PNPLA2 (NP_0651091) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.24 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855600 |
Product Specific Information
Immunogen sequence:
GASAGALTAT ALVTGVCLGE AGAKFIEVSK EARKRFLGPL HPSFNLVKII RSFLLKVLPA DSHEHASGRL GISLTRVSDG ENVIISHFNS KDELIQANVC SGFIPVYCGL IPPSLQGVRY VDGGISDNLP LYELKNTITV SPFSGESDIC PQDSSTNIHE LRVTNTSIQF NLRNLYRLSK ALFPPEPLVL REMCKQGYRD GLRFLQRNGL LNR
Target Information
Lipolytic enzymes are essential for mobilizing fatty acids from triglyceride stores in adipose tissue. Dysfunctional lipolysis affects energy homeostasis and may contribute to obesity and insulin resistance. Hormone-sensitive lipase (HSL) was previously known as the sole triglyceride-hydrolyzing enzyme in mammalian adipose tissue. However, adipose triglyceride lipase (ATGL) is now recognized as catalyzing the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans, exhibits high substrate specificity for triacylglycerol, and associates with lipid droplets. Inhibition of ATGL significantly reduces total adipose acyl-hydrolase activity, indicating that ATGL and HSL coordinate triglyceride catabolism in mammalian adipose tissue.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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