Thermo Fisher Scientific RING1 Monoclonal Antibody (OTI2D11), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:250

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

RING1 belongs to the RING finger family, encoding proteins with a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product binds DNA and acts as a transcriptional repressor, associated with the polycomb group protein complex. It interacts with BMI1, EDR1, and CBX4, colocalizing in large nuclear domains, and binds CBX4 via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, contiguous with RING finger genes FABGL and HKE4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.