Thermo Fisher Scientific CD28 Monoclonal Antibody (CD28.2), FITC, eBioscience

Applications

Flow Cytometry (Flow)

• Tested Dilution: 5 µL (1 µg)/test
• Publications: View 20 publications

Functional Assay (Functional)

• Tested Dilution: -
• Publications: View 2 publications

T-Cell Activation (TCA)

• Tested Dilution: -
• Publications: View 3 publications

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 700
• APC
• APC-eFluor 780
• Biotin
• Brilliant UV 395
• Brilliant UV 615
• Brilliant UV 737
• Brilliant Violet 480
• Brilliant Violet 650
• Brilliant Violet 786
• eFluor 450
• Functional Grade
• NovaFluor Blue 610-70S
• NovaFluor Blue 660-120S
• NovaFluor Blue 690
• NovaFluor Red 710
• NovaFluor Red 725
• NovaFluor Red 755
• NovaFluor Yellow 660
• NovaFluor Yellow 755
• PE
• PE-Cyanine7
• PE-eFluor 610
• PerCP-Cyanine5.5
• Super Bright 436
• Super Bright 600
• Super Bright 645
• Request custom conjugation

Product Specific Information

The CD28.2 monoclonal antibody reacts with the human CD28 molecule, a 44 kDa homodimer expressed by thymocytes, mature T cells, and plasma cells.
CD28 is a ligand for CD80 (B7-1) and CD86 (B7-2) and is a potent co-stimulator of T cells. Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells.

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested on normal human peripheral blood cells. Use at 5 µL (1 µg) per test (100 µL final volume).
Excitation: 488 nm
Emission: 520 nm
Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein.
It is a cell adhesion molecule of the immunoglobulin superfamily, constitutively expressed on most peripheral blood T lymphocytes.
CD28 provides critical co-stimulatory signals to T cells by binding CD80 and CD86 on antigen-presenting cells, preventing anergy and premature apoptosis.
In murine lymphoid organs, all CD4+ and CD8+ T cells express CD28, with variable expression during thymocyte maturation.
Diseases associated with CD28 dysfunction include mycosis fungoides and Sezary’s Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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