Thermo Fisher Scientific MKP3 Polyclonal Antibody
MKP3 단백질 인식용 Thermo Fisher Scientific의 폴리클로날 항체로, Human, Mouse, Pig, Rat에 반응합니다. Western blot에 적합하며, 비결합(Unconjugated) 액상 형태로 제공됩니다. DUSP6 단백질 인산화 효소 억제 연구에 활용됩니다.
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Applications
- Western Blot (WB): 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-PSNQNVYQVDSLQST (aa 367–381) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933637 |
Product Specific Information
- This antibody is expected to recognize both reported isoforms (NP_001937.2; NP_073143.2).
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.
Different members of this phosphatase family show distinct substrate specificities, tissue distribution, subcellular localization, and inducibility by extracellular stimuli. The DUSP6 gene product inactivates ERK2, is highly expressed in heart and pancreas, and is localized in the cytoplasm. Two transcript variants encoding different isoforms have been reported.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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