Thermo Fisher Scientific CDC20 Polyclonal Antibody
Human CDC20 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ELISA, IP에 사용 가능. 고농도(85 mg/mL) 액상 형태이며, -20°C에서 보관. 세포주기 조절 관련 연구에 적합한 연구용 항체.
- 카탈로그번호
- 100-401-A17
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | Assay-dependent |
| ELISA | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 486–499 of Human CDC20 (C-terminal) coupled to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 85 mg/mL |
| Storage Buffer | Whole serum |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening.
Aliquot contents and freeze at -20°C or below for extended storage.
Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
Stable for several weeks at 4°C as an undiluted liquid.
Dilute only prior to immediate use.
This product reacts with human CDC20 (fizzy).
Cross-reactivity may occur with CDC20 from other sources.
Target Information
CDC20 is required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex.
It is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive, and in anaphase the CDC20-APC/C binary complex is active in degrading substrates.
The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at the presynaptic membrane in postmitotic neurons.
CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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