Thermo Fisher Scientific MYOC Polyclonal Antibody
Rabbit polyclonal antibody against human MYOC detecting endogenous 57 kDa protein. Validated for Western blot. High purity (>95%) and antigen affinity purified. Supplied as liquid in PBS with glycerol and sodium azide. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length human MYOC (amino acids 1–504) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2554038 |
Product Specific Information
- Detects endogenous MYOC protein at approximately 57 kDa.
- Purity >95% by SDS-PAGE.
Target Information
Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork, and ciliary body. It can form homomultimers in vivo and associate with extracellular matrix components via interactions with the Hep II domain of FibroPVRL1. Myocilin also interacts with myosin regulatory light chain, linking it to the actomyosin system and the functional status of the trabecular meshwork (TM), which regulates intraocular pressure (IOP). Dysfunction of TM may lead to elevated IOP and glaucoma development. The MYOC gene (also known as TIGR) maps to chromosome 1q24.3 and is associated with primary open-angle glaucoma (POAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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