Thermo Fisher Scientific DR3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human DR3 for research use. Suitable for WB, IHC(F), and ICC/IF applications. Unconjugated, liquid form, 1 mg/mL concentration. Store at 4°C short term or -20°C long term to maintain stability.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–5 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide from extracellular domain of human DR3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1957924 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DR3 (TNFRSF25) is a member of the TNF-receptor superfamily, expressed predominantly in lymphocyte-rich tissues. It plays a role in lymphocyte homeostasis, stimulates NF-kappa B activity, and regulates apoptosis. Signal transduction occurs via death domain-containing adaptor proteins. Knockout studies in mice suggest DR3/TNFRSF25 contributes to the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants exist, with most encoding potentially secreted molecules. Upon T-cell activation, alternative splicing produces full-length, membrane-bound isoforms, which may regulate lymphocyte proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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