Thermo Fisher Scientific DR4 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human DR4 (TRAIL-R1). Validated for Western blot at 1:500–1:1,000 dilution. Supplied as a 1 mg/mL liquid unconjugated antibody. Suitable for apoptosis and TNF receptor pathway studies. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
Product Specifications
| Category | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide from amino terminus of human DR4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1957931 |
Product Specific Information
Store as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also known as TRAIL receptor 1. It binds TRAIL, a ligand belonging to the TNF family. DR4 mediates apoptosis and NF-κB activation in various cells and tissues. Apoptosis, or programmed cell death, is essential for normal cellular differentiation and development in multicellular organisms. It is induced by interactions between cytokines (such as TNF, Fas ligand) and their death domain-containing receptors (TNFR1, Fas receptor).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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