Thermo Fisher Scientific CD61 (Integrin beta 3) Monoclonal Antibody (JM2E5)
돼지 CD61 항원을 인식하는 단클론 항체로, 혈소판 및 내피세포 연구에 적합합니다. Western blot, IHC, Flow cytometry 등 다양한 응용에 사용 가능하며, Protein A 정제 및 PBS 완충액에 보존됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Flow Cytometry (Flow) | 1:50–1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Pig |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | JM2E5 |
| Immunogen | Porcine peripheral blood mononuclear cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745378 |
Available Formats
Product Specific Information
This antibody recognizes the porcine CD61 cell surface antigen, also known as platelet glycoprotein IIIa. CD61 is present on the megakaryocyte/platelet lineage, granulocytes, cells from the monocyte/macrophage lineage, and endothelial cells.
Target Information
CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets, and their precursors. It plays a role in platelet aggregation and serves as a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin. CD61 (105 kDa) associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface.
CD61 is expressed on:
- Platelets and megakaryocytes (with CD41)
- Endothelial cells, monocytes, and osteoclasts (with CD51)
It participates in cell adhesion and signaling. Dysfunction of CD61 is associated with Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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