Thermo Fisher Scientific GCH1 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  PPRPEAKSAQ PADGWKGERP RSEEDNELNL PNLAAAYSSI LSSLGENPQR
• Storage guidance:
  For short term use, store at 2–8°C up to 1 week.
  For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted homology:
  Cow: 100%
  Dog: 100%
  Human: 100%
  Rabbit: 100%
  Rat: 86%

Target Information

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases and nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, but not all variants produce functional enzymes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.