Thermo Fisher Scientific TREX1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

Trex1 (ATRIP) is the major human 3′ to 5′ exonuclease required for checkpoint signaling after DNA damage. It is ubiquitously expressed and binds to single-stranded DNA coated with replication protein A at sites of DNA damage. It recruits the ATR checkpoint kinase to sites of DNA damage and replication stress and is required for ATR expression.
This gene uses two different open reading frames:

• The upstream ORF encodes proteins that interact with ATR and localize to intranuclear foci induced by DNA damage, functioning as essential components of the DNA damage checkpoint.
• The downstream ORF encodes proteins with 3′ to 5′ exonuclease activity and may be a subunit of human DNA polymerase III.

Multiple transcript variants encoding different isoforms have been identified. Mutations in this gene are associated with Aicardi-Goutières syndrome, chilblain lupus, and Cree encephalitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.