Thermo Fisher Scientific PIK3C2A Monoclonal Antibody (OTI3F8), TrueMAB
PIK3C2A 단백질을 인식하는 마우스 단클론 항체로 Western Blot 및 IHC(Paraffin)에 적합. 인간 단백질에 반응하며 고순도 친화 크로마토그래피로 정제됨. 액상 형태, 안정적인 PBS/BSA/glycerol 버퍼에 보관 가능.
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- TA801641
- 판매단위
- pk
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Thermo Fisher Scientific PIK3C2A Monoclonal Antibody (OTI3F8), TrueMAB
Applications and Tested Dilution
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F8 |
| Immunogen | Human recombinant protein fragment (aa 230–560 of human PIK3C2A) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Class II PI3 kinases, including PIK3C2A, phosphorylate the 3-position of PI or PI4P. Although less studied than Class I PI3 kinases, Class II enzymes are involved in diverse receptor-mediated cellular processes such as insulin signaling, neuronal survival, and growth factor signaling.
PI3-kinases play critical roles in pathways regulating cell proliferation, oncogenic transformation, cell survival, migration, and intracellular trafficking.
PIK3C2A contains a lipid kinase catalytic domain and a C-terminal C2 domain, characteristic of Class II PI3-kinases. C2 domains serve as calcium-dependent phospholipid binding motifs facilitating membrane translocation and protein-protein interactions.
This protein’s PI3-kinase activity is not sensitive to nanomolar levels of wortmannin and can be activated by insulin, suggesting involvement in integrin-dependent signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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