Thermo Fisher Scientific PIK3C2A Monoclonal Antibody (OTI3G9), TrueMAB
Human PIK3C2A 단백질(아미노산 230-560)에 특이적인 Mouse IgG1 단클론 항체. Western blot에 최적화(1:2,000 희석). 액상 형태, 1 mg/mL 농도, Affinity chromatography로 정제. 세포 신호전달 및 인슐린 경로 연구용.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 230–560 of human PIK3C2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Although less studied than Class I PI3 kinases, Class II enzymes are linked to diverse receptor-mediated cellular processes such as insulin signaling, neuronal survival, and growth factor signaling.
PI3-kinases participate in pathways involved in cell proliferation, oncogenic transformation, survival, migration, and intracellular trafficking.
PIK3C2A contains a lipid kinase catalytic domain and a C-terminal C2 domain, characteristic of Class II PI3-kinases. C2 domains act as calcium-dependent phospholipid-binding motifs that mediate protein translocation to membranes and protein-protein interactions.
Its PI3-kinase activity is not sensitive to nanomolar levels of the inhibitor wortmannin. The protein can be activated by insulin and may be involved in integrin-dependent signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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