Thermo Fisher Scientific PIK3C2A Monoclonal Antibody (OTI1B5), TrueMAB
인간 PIK3C2A 단백질(aa 230-560)에 특이적인 Mouse IgG2b 단일클론 항체. Western blot에 최적화(1:2000 희석). 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol 버퍼 포함. 세포 신호전달 및 PI3 kinase 연구용.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 230–560 of human PIK3C2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as Class I PI3 kinases, Class II enzymes are involved in diverse receptor-mediated cellular processes such as insulin signaling, neuronal survival, and growth factor signaling.
PI3-kinases play roles in pathways regulating cell proliferation, oncogenic transformation, survival, migration, and intracellular protein trafficking.
PIK3C2A contains a lipid kinase catalytic domain and a C-terminal C2 domain, characteristic of Class II PI3-kinases. The C2 domain acts as a calcium-dependent phospholipid binding motif mediating membrane translocation and protein interactions.
This protein’s PI3-kinase activity is not sensitive to nanomolar levels of wortmannin and can be activated by insulin, suggesting involvement in integrin-dependent signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: TA801642_PIK3C2A_O00443-1_House_mouse.svg / TA801642_PIK3C2A_O00443-1_House_mouse_PDP.jpeg)
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