Thermo Fisher Scientific LSM11 Monoclonal Antibody (OTI1A4), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

LSm11 is a 360 amino acid protein localized in the nucleus, belonging to the LSm subfamily of snRNP Sm proteins. It contains an N-terminal domain necessary for pre-mRNA cleavage and binds specifically to U7 snRNA. LSm11 is implicated in cell cycle regulation and cell growth.
The LSm11 gene is located on human chromosome 5, which spans approximately 181 million base pairs (~6% of the human genome). Deletion of the p arm of chromosome 5 causes Cri du chat syndrome, while deletions of the q arm or entire chromosome 5 are associated with therapy-related acute myelogenous leukemia and myelodysplastic syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.