Thermo Fisher Scientific CD278 (ICOS) Monoclonal Antibody (ISA-3), APC-eFluor 780, eBioscience
인간 ICOS(CD278)를 인식하는 ISA-3 단클론 항체로, APC-eFluor 780 형광체가 결합되어 있습니다. 유세포분석(Flow Cytometry)에 최적화되어 있으며, 5 µL/test로 사용 가능합니다. 활성화된 T세포의 공동자극 분석에 적합합니다. 4°C 암소 보관, 동결 금지.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 5 µL (0.125 µg)/test | View 11 publications |
| Functional Assay | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC-eFluor™ 780, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ISA-3 |
| Conjugate | APC-eFluor™ 780 |
| Excitation/Emission Max | 756/785 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Wet ice |
| RRID | AB_2573999 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- Biotin
- Brilliant UV 661
- eFluor 450
- FITC
- Functional Grade
- NovaFluor Red 660
- NovaFluor Red 710
- NovaFluor Yellow 700
- NovaFluor Yellow 730
- PE
- PE-Cyanine5.5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Super Bright 780
- Request custom conjugation
Product Specific Information
The ISA-3 monoclonal antibody reacts with human ICOS (Inducible COStimulatory molecule), also known as H4, CRP-1, and AILIM.
ICOS is a T-cell-specific activation molecule and a member of the CD28/CTLA-4 family. It plays a critical role in T-cell activation and humoral immune responses, particularly in memory B cell and plasma cell generation.
- ICOS binds to its ligand B7h/B7RP-1 expressed on activated APCs and inflamed tissues.
- Plate-bound ISA-3 induces IL-4, IL-5, IL-10 production but not IL-2.
- ISA-3 was generated against human ICOS antigen.
- Clone C398.4A (anti-mouse ICOS/H4) cross-reacts with human ICOS but binds a different epitope.
- For brightest staining of activated human T cells, use Product #13-9948-82 or #12-9948-42.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested on normal human peripheral blood cells at 5 µL (0.125 µg)/test.
Laser Excitation: Red laser (633 nm)
Emission: 780 nm
Light Sensitivity: Protect from light due to photo-induced oxidation.
Fixation: Samples can be stored in IC Fixation Buffer (Product #00-8222) or 1-step Fix/Lyse Solution (Product #00-5333) for up to 3 days at 4°C in the dark.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
ICOS (CD278) encodes a protein in the CD28/CTLA-4 receptor family.
It functions as a homodimer and plays a crucial role in:
- Cell-cell signaling
- Immune response regulation
- Cell proliferation control
ICOS is associated with disorders such as Common Variable Immunodeficiency (CVID).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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