Thermo Fisher Scientific DMGDH Polyclonal Antibody
Rabbit polyclonal antibody recognizing human DMGDH protein. Validated for ICC/IF applications. Purified by antigen affinity chromatography and supplied in PBS with glycerol. Suitable for research use to study choline metabolism and DMGDH-related pathways.
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Applications
Tested Application and Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human DMGDH. Recombinant protein control fragment (Product #RP-108127) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2665085 |
Product Specific Information
Immunogen sequence:
AGARKCGALLK YPAPVTSLKA RSDGTWDVET PQGSMRANRI VNAAGFWARE VGKMIGLEHP LIPVQHQYVV TSTISEVK
Highest antigen sequence identity to the following orthologs:
- Mouse: 92%
- Rat: 90%
Target Information
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix and uses flavin adenine dinucleotide and folate as cofactors.
Mutations in this gene cause dimethylglycine dehydrogenase deficiency, characterized by fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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